Abstract
Aliphatic carboxylic acids are abundant in natural and synthetic sources and are widely used as connection points in many chemical transformations. Radical decarboxylative functionalization promoted by transition-metal catalysis has achieved great success, enabling carboxylic acids to be easily transformed into a wide variety of products. Herein, we highlight the recent advances made on transition-metal (Ni, Cu, Fe, Co or Cr) catalyzed C–X (X = C, N, H, O, B, or Si) bond formation as well as syntheses of ketones, amino acids, alcohols, ethers and difluoromethyl derivatives via radical decarboxylation of carboxylic acids or their derivatives, including, among others, redox-active esters (RAEs), anhydrides, and diacyl peroxides.
1 Introduction
2 Ni-Catalyzed Decarboxylative Functionalizations
3 Cu-Catalyzed Decarboxylative Functionalizations
4 Fe-Catalyzed Decarboxylative Functionalizations
5 Co- and Cr-Catalyzed Decarboxylative Functionalizations
6 Conclusions
Publication HistoryReceived: 24 June 2020Accepted after revision: 04 August 2020Publication Date:01 October 2020 (online)
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